Long-Sen Chang Selected Research

Cardiotoxins

12/2021	Naja atra Cardiotoxin 1 Induces the FasL/Fas Death Pathway in Human Leukemia Cells.
12/2019	Naja atra Cardiotoxin 3 Elicits Autophagy and Apoptosis in U937 Human Leukemia Cells through the Ca2+/PP2A/AMPK Axis.
10/2012	Cardiotoxin III suppresses MDA-MB-231 cell metastasis through the inhibition of EGF/EGFR-mediated signaling pathway.
1/2012	Antimetastatic potential of cardiotoxin III involves inactivation of PI3K/Akt and p38 MAPK signaling pathways in human breast cancer MDA-MB-231 cells.
10/2009	Inactivation of epidermal growth factor receptor and downstream pathways in oral squamous cell carcinoma Ca9-22 cells by cardiotoxin III from Naja naja atra.
1/2009	Effects of cardiotoxin III on NF-kappaB function, proliferation, and apoptosis in human breast MCF-7 cancer cells.
8/2008	Involvement of mitochondrial alteration and reactive oxygen species generation in Taiwan cobra cardiotoxin-induced apoptotic death of human neuroblastoma SK-N-SH cells.
3/2008	Taiwan cobra cardiotoxins induce apoptotic death of human neuroblastoma SK-N-SH cells mediated by reactive oxygen species generation and mitochondrial depolarization.
6/2007	Involvement of c-jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by cardiotoxin III (Naja naja atra) in K562 leukemia cells.

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Long-Sen Chang Research Topics

Disease

45	Leukemia 07/2022 - 06/2007
30	Neoplasms (Cancer) 01/2022 - 06/2007
15	Breast Neoplasms (Breast Cancer) 09/2021 - 02/2010
10	Neuroblastoma 09/2010 - 02/2008
9	Neoplasm Metastasis (Metastasis) 11/2016 - 02/2010
5	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 03/2022 - 01/2020
5	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2022 - 10/2009
5	Melanoma (Melanoma, Malignant) 10/2017 - 06/2007
3	Squamous Cell Carcinoma of Head and Neck 09/2010 - 10/2009
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 05/2014 - 10/2009
2	Adenocarcinoma of Lung 01/2010 - 09/2009
2	Mitochondrial Diseases (Mitochondrial Disease) 08/2009 - 06/2007
1	Respiratory Tract Infections (Respiratory Tract Infection) 01/2021
1	Juvenile Arthritis (Juvenile Idiopathic Arthritis) 01/2021
1	autosomal dominant familial Periodic fever 01/2021
1	Inflammation (Inflammations) 01/2021
1	Cryopyrin-Associated Periodic Syndromes 01/2021
1	Carcinogenesis 01/2015

Drug/Important Bio-Agent (IBA)

19	p38 Mitogen-Activated Protein KinasesIBA 03/2022 - 07/2008
9	CardiotoxinsIBA 12/2021 - 06/2007
8	Phospholipases (Phospholipase)IBA 11/2011 - 01/2009
7	hydroquinone (Esoterica)FDA Link 07/2022 - 04/2013
6	VenomsIBA 03/2016 - 06/2007
6	Caspase 8 (Caspase-8)IBA 01/2016 - 12/2009
6	N-formyl-13-dihydrocarminomycin (NFD)IBA 09/2014 - 01/2010
5	Cobra Cardiotoxin ProteinsIBA 12/2021 - 08/2008
5	Proteins (Proteins, Gene)FDA Link 01/2021 - 02/2010
5	Epidermal Growth Factor (EGF)IBA 11/2016 - 06/2010
5	Matrix Metalloproteinase 2 (Gelatinase A)IBA 12/2014 - 09/2010
5	Phospholipases A2 (Phospholipase A2)IBA 12/2014 - 07/2008
5	furanIBA 02/2014 - 01/2010
4	Messenger RNA (mRNA)IBA 01/2022 - 09/2010
4	Matrix Metalloproteinase 9 (Gelatinase B)IBA 11/2016 - 12/2014
4	Matrix Metalloproteinases (MMPs)IBA 12/2014 - 09/2012
4	CaspasesIBA 09/2011 - 06/2007
3	Sirtuin 3IBA 03/2022 - 01/2019
3	Benzene (Benzole)IBA 03/2022 - 01/2020
3	Amsacrine (AMSA)IBA 01/2018 - 05/2014
3	Gallic AcidIBA 11/2016 - 09/2012
3	Peptides (Polypeptides)IBA 03/2016 - 06/2007
3	notexinIBA 12/2014 - 01/2010
3	ErbB Receptors (EGF Receptor)IBA 02/2013 - 10/2009
3	IN6CPBDIBA 09/2011 - 06/2007
3	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2010 - 03/2008
3	Arachidonic Acid (Vitamin F)IBA 03/2010 - 08/2009
3	DiaminesIBA 09/2009 - 10/2007
2	Protein Phosphatase 2 (Protein Phosphatase 2A)IBA 03/2022 - 09/2013
2	Daunorubicin (Cerubidine)FDA LinkGeneric 01/2022 - 11/2021
2	SurvivinIBA 01/2021 - 01/2020
2	sepantroniumIBA 01/2021 - 01/2020
2	AnthelminticsIBA 05/2020 - 01/2019
2	Albendazole (Albenza)FDA Link 05/2020 - 01/2019
2	Arsenic Trioxide (Trisenox)FDA Link 04/2020 - 11/2018
2	Pharmaceutical PreparationsIBA 01/2020 - 06/2007
2	navitoclaxIBA 01/2020 - 01/2018
2	Quinacrine (Mepacrine)IBA 11/2017 - 04/2015
2	Type II Tumor Necrosis Factor ReceptorsIBA 01/2016 - 05/2012
2	DNA (Deoxyribonucleic Acid)IBA 10/2015 - 09/2011
2	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 09/2014 - 08/2014
2	Caffeine (No Doz)FDA LinkGeneric 09/2013 - 09/2010
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2013 - 05/2012
2	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 04/2013 - 07/2008
2	3,3',4,5'-tetrahydroxystilbeneIBA 09/2012 - 09/2010
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/2011 - 11/2008
2	Protease Inhibitors (Protease Inhibitor)IBA 10/2010 - 02/2010
2	Mitogen-Activated Protein KinasesIBA 01/2010 - 09/2009
2	Amino Acids FDA Link 10/2009 - 06/2007
2	NF-kappa B (NF-kB)IBA 01/2009 - 07/2008
2	Antineoplastic Agents (Antineoplastics)IBA 11/2008 - 08/2008
1	WEHI-539IBA 07/2022
1	venetoclaxIBA 07/2022
1	TristetraprolinIBA 03/2022
1	Docetaxel (Taxotere)FDA Link 01/2022
1	carbamylhydrazine (semicarbazide)IBA 09/2021
1	Lactalbumin (alpha-Lactalbumin)IBA 09/2021
1	Monoclonal AntibodiesIBA 01/2021
1	Glycogen Synthase KinasesIBA 01/2021
1	canakinumab FDA Link 01/2021
1	InterleukinsIBA 01/2021
1	Peroxidase (Myeloperoxidase)IBA 01/2021
1	benzimidazoleIBA 05/2020
1	Pemetrexed (MTA)FDA Link 05/2020
1	Vincristine (Oncovin)FDA LinkGeneric 01/2020
1	Protein Kinases (Protein Kinase)IBA 12/2019
1	thiamine triphosphorate (TTP)IBA 01/2019
1	Antimalarials (Antimalarial Agents)IBA 11/2017
1	TriazolesIBA 10/2017
1	Proto-Oncogene Proteins c-bcl-2 (Proto Oncogene Proteins c bcl 2)IBA 03/2017
1	Type II DNA Topoisomerases (Topoisomerase II)IBA 03/2017
1	Aminacrine (Aminoacridine)IBA 03/2017
1	PhytochemicalsIBA 11/2016
1	GoldIBA 11/2016
1	2-(4-aminophenyl)-7-methoxybenzothiazoleIBA 01/2016
1	GlucuronidesIBA 01/2015
1	CarcinogensIBA 01/2015
1	GlucuronidaseIBA 01/2015
1	Simvastatin (Zocor)FDA LinkGeneric 12/2014
1	LuciferasesIBA 05/2014

Therapy/Procedure

4	Therapeutics 01/2021 - 10/2010
2	Photochemotherapy (Photodynamic Therapy) 10/2017 - 08/2010